High-dose pharmaceutical grade biotin (MD1003) in amyotrophic lateral sclerosis: A pilot study
نویسندگان
چکیده
منابع مشابه
MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: A randomised, double-blind, placebo-controlled study
BACKGROUND Treatment with MD1003 (high-dose biotin) showed promising results in progressive multiple sclerosis (MS) in a pilot open-label study. OBJECTIVE To confirm the efficacy and safety of MD1003 in progressive MS in a double-blind, placebo-controlled study. METHODS Patients (n = 154) with a baseline Expanded Disability Status Scale (EDSS) score of 4.5-7 and evidence of disease worsenin...
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Behçet’s disease is a multisystem vasculitis. Its neurological involvement mostly includes parenchymal and non-parenchymal central nervous system manifestations. Peripheral nervous system presentations are rare. A 32-yr-old male patient who fulfilled the international study group criteria for Behçet’s disease, referred to our center with walking difficulty and repeated falling downs. Neurologi...
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Amyotrophic lateral sclerosis (ALS) is a fatal incurable neurodegenerative disease whose etiology is unknown and pathogenesis is still not fully understood. A great majority of its cases are sporadic. Clinical ALS signs are caused by damage and dying-out of the lower and upper motor neurons. This study was aimed at identifying possible sporadic ALS-associated aberrations in the spinal cord expr...
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ژورنال
عنوان ژورنال: EClinicalMedicine
سال: 2020
ISSN: 2589-5370
DOI: 10.1016/j.eclinm.2019.100254